Selected scientific publications on diving medicine and physiology.

2022 Dec 30
Oxidative Stress Response's Kinetics after 60 Minutes at Different (30% or 100%) Normobaric Hyperoxia Exposures
Leveque C, Mrakic-Sposta S, Lafere P, Vezzoli A, Germonpre P, Beer A, Mievis S, Virgili F, Lambrechts K, Theunissen S, Guerrero F & Balestra C.

Oxygen is a powerful trigger for cellular reactions and is used in many pathologies, including oxidative stress. However, the effects of oxygen over time and at different partial pressures remain poorly understood. In this study, the metabolic responses of normobaric oxygen intake for 1 h to mild (30%) and high (100%) inspired fractions were investigated. Fourteen healthy non-smoking subjects (7 males and 7 females; age: 29.9 ± 11.1 years, height: 168.2 ± 9.37 cm; weight: 64.4 ± 12.3 kg; BMI: 22.7 ± 4.1) were randomly assigned in the two groups. Blood samples were taken before the intake at 30 min, 2 h, 8 h, 24 h, and 48 h after the single oxygen exposure.

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2022 Dec 21
The Normobaric Oxygen Paradox-Hyperoxic Hypoxic Paradox: A Novel Expedient Strategy in Hematopoiesis Clinical Issues
Salvagno M, Coppalini G, Taccone FS, Strapazzon G, Mrakic-Sposta S, Rocco M, Khalife M & Balestra C.

Hypoxia, even at non-lethal levels, is one of the most stressful events for all aerobic organisms as it significantly affects a wide spectrum of physiological functions and energy production. Aerobic organisms activate countless molecular responses directed to respond at cellular, tissue, organ, and whole-body levels to cope with oxygen shortage allowing survival, including enhanced neo-angiogenesis and systemic oxygen delivery.

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2022 Jan 15
Full-Face Mask Use during SCUBA Diving Counters Related Oxidative Stress and Endothelial Dysfunction
Morgan Levenez, Kate Lambrechts, Simona Mrakic-Sposta, Alessandra Vezzoli, Peter Germonpré, Hadrien Pique, Fabio Virgili, Gerardo Bosco, Pierre Lafère and Costantino Balestra

Abstract: Impaired flow mediated dilation (FMD), an index of vascular stress, is known after SCUBA diving. This is related to a dysfunction of nitric oxide (NO) availability and a disturbance of the redox status, possibly induced by hyperoxic/hyperbaric gas breathing.

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2022 Jan 18
White Blood Cells, Platelets, Red Blood Cells and Gas Bubbles in SCUBA Diving: Is There a Relationship?
Cialoni D, Brizzolari A, Barassi A, Bosco G, Pieri M, Lancellotti V, Marroni A.

Background: SCUBA diving can influence changes of several hematological parameters (HP) but the changes of HP in the decompression phases are still unclear. The aim of this study was to investigate any possible relationship between HP and predisposition to inert gas bubble formation after a single recreational dive.

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2021 Nov 28
Physiology of repeated mixed gas 100-m wreck dives using a closed-circuit rebreather: a field bubble study
Balestra C, Guerrero F, Theunissen S, Germonpre P & Lafere P.

Purpose Data regarding decompression stress after deep closed-circuit rebreather (CCR) dives are scarce. This study aimed to monitor technical divers during a wreck diving expedition and provide an insight in venous gas emboli (VGE) dynamics. Methods Diving practices of ten technical divers were observed. They performed a series of three consecutive daily dives around 100 m.

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