Selected scientific publications on diving medicine and physiology.

2020 Sep 28
Change in Oxidative Stress Biomarkers During 30 Days in Saturation Dive: A Pilot Study
Mrakic-Sposta S, Vezzoli A, D'Alessandro F, Paganini M, Dellanoce C, Cialoni D, Bosco G.

Saturation diving allows divers to reduce the risk of decompression sickness while working at depth for prolonged periods but may increase reactive oxygen species (ROS) production. Such modifications can affect endothelial function by exacerbating oxidative stress. This study investigated the effects of saturation diving on oxidative stress damage.

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2020 Jun 30
Experimental use of flow cytometry to detect bacteria viability after hyperbaric oxygen exposure: Work in progress report
Rozloznik M, Lochmanova A, Chmelar D, Hajek M, Korytkova K, Cisarikova M.

Introduction: Hyperbaric oxygen treatment (HBOT), based on inhaling pure oxygen under elevated ambient pressure, is used as adjuvant intervention to promote healing in infected wounds. Despite extensive clinical evidence of beneficial effects of HBOT in soft tissue infections the mechanism of action remains to be elucidated. The aim of this study was to evaluate the use of flow cytometry as a novel method to assess the viability of pathogenic bacteria after hyperbaric oxygen (HBO) exposure.

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2019 Jun 30
Early detection of diving-related cognitive impairment of different nitrogen-oxygen gas mixtures using critical flicker fusion frequency.
Lafère P, Hemelryck W, Germonpré P, Matity L, Guerrero F, Balestra C.

Introduction: Cognitive impairment related to inert gas narcosis (IGN) is a threat to diving safety and operations at depth that might be reduced by using enriched air nitrox (EANx) mixtures. Using critical flicker fusion frequency (CFFF), a possible early detection of cognitive abilities/cerebral arousal impairment when breathing different oxygen (O2) fractions was investigated.

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2020 Jan 1
Hyperoxia and oxidative stress in anesthesia and critical care medicine
Ottolenghi S, Sabbatini G, Brizzolari A, Samaja M, Chiumello D.

Oxygen administration is particularly relevant in patients undergoing surgery under general anesthesia and in those who suffer from acute or critical illness. Nevertheless, excess O2, or hyperoxia, is also known to be harmful. Toxicity arises from the enhanced formation of reactive oxygen species (ROS) that, exceeding the antioxidant defense, may generate oxidative stress.

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2019 Jun 26
Variation of Cognitive Function During a Short Stay at Hypobaric Hypoxia Chamber (Altitude: 3842 M)
De Bels D, Pierrakos C, Bruneteau A, Reul F, Crevecoeur Q, Marrone N, Vissenaeken D, Borgers G, Balestra C, Honore PM & Theunissen S.

Objective To observe the effects of a fast-acute ascent to high altitude on brain cognitive function and transcranial doppler parameters in order to understand the physiological countermeasures of hypoxia. Methods 17 high-altitude-naïve male subjects (mean age was 26.3 ± 8.1 years) participated in the study. We measured Critical Flicker Fusion Frequency (CFFF), blood oxygen saturation, Psychology Experiment Building (PEBL) including three tests (Modified Math Processing Task, Perceptual Vigilance Task, and Time Estimation Task), as well as Cerebral Blood Flow index (CBFi), mean cerebral artery Systolic and diastolic velocities, Cerebral Pulsatility index (CPi), and heart Rate. All were measured at sea level, at least 1 h after arrival at the hypobaric hypoxia equivalent of 3842 m and 1 h after return to sea level.

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