Wetenschappelijke artikelen
Geselecteerde wetenschappelijke artikelen over duikgeneeskunde en -fysiologie
2021 jul 28
High-Throughput Griess Assay of Nitrite and Nitrate in Plasma and Red Blood Cells for Human Physiology Studies under Extreme Conditions
Brizzolari, A.; Dei Cas, M.; Cialoni, D.; Marroni, A.; Morano, C.; Samaja, M.; Paroni, R.; Rubino, F.M.

The metabolism of nitric oxide plays an increasingly interesting role in the physiological response of the human body to extreme environmental conditions, such as underwater, in an extremely cold climate, and at low oxygen concentrations.

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2020 feb 12
Hyperoxia Alters Ultrastructure and Induces Apoptosis in Leukemia Cell Lines
David De Bels, Frauke Tillmans, Francis Corazza, Mariano Bizzarri, Peter Germonpre, Peter Radermacher, Keziban Günce Orman, and Costantino Balestra

Oxygenation conditions are crucial for growth and tumor progression. Recent data suggests a decrease in cancer cell proliferation occurring after exposure to normobaric hyperoxia. Those changes are associated with fractal dimension. The purpose of this research was to study the impact of hyperoxia on apoptosis and morphology of leukemia cell lines. Two hematopoietic lymphoid cancer cell lines (a T-lymphoblastoid line, JURKAT and a B lymphoid line, CCRF-SB) were tested under conditions of normobaric hyperoxia (FiO2 > 60%, ± 18h) and compared to a standard group (FiO2 = 21%). We tested for apoptosis using a caspase-3 assay.

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2021 sep 4
Hypoxic and Hyperoxic Breathing as a Complement to Low-Intensity Physical Exercise Programs: A Proof-of-Principle Study
Balestra C, Lambrechts K, Mrakic-Sposta S, Vezzoli A, Levenez M, Germonpre P, Virgili F, Bosco G, Lafere P

Inflammation is an adaptive response to both external and internal stimuli including infection, trauma, surgery, ischemia-reperfusion, or malignancy. A number of studies indicate that physical activity is an effective means of reducing acute systemic and low-level inflammation occurring in different pathological conditions and in the recovery phase after disease. As a proof-of-principle, we hypothesized that low-intensity workout performed under modified oxygen supply would elicit a “metabolic exercise” inducing a hormetic response, increasing the metabolic load and oxidative stress with the same overall effect expected after a higher intensity or charge exercise.

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2021 mei 13
Impaired Attentional Processing During Parabolic Flight
Friedl-Werner A, Machado M-L, Balestra C, Liegard Y, Philoxene B, Brauns K, Stahn AC, Hitier M, Besnard S.

Previous studies suggest that altered gravity levels during parabolic flight maneuvers affect spatial updating. Little is known about the impact of the experimental setting and psychological stressors associated with parabolic flight experiments on attentional processes. To address this gap, we investigated the level of alertness, selective and sustained attention in 1 and 0 g using a Go/No-Go Continuous Performance Task. We also identified several parameters associated with the experimental set-up of a parabolic flight that could be expected to affect attentional processing.

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2021 okt 29
Increased Risk of Decompression Sickness When Diving With a Right-to-Left Shunt: Results of a Prospective Single-Blinded Observational Study (The “Carotid Doppler” Study)
Germonpré Peter, Lafère Pierre, Portier William, Germonpré Faye-Lisa, Marroni Alessandro, Balestra Costantino

Introduction: Divers with a patent Foramen Ovale (PFO) have an increased risk for decompression sickness (DCS) when diving with compressed breathing gas. The relative risk increase, however, is difficult to establish as the PFO status of divers is usually only determined after a DCS occurrence.

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