Publications

Selected scientific publications on diving medicine and physiology.

2017 May 1
Objective vs. Subjective Evaluation of Cognitive Performance During 0.4-MPa Dives Breathing Air or Nitrox
Germonpré P., Balestra C., Hemelryck W., Buzzacott P., Lafère P.

BACKGROUND: Divers try to limit risks associated with their sport, for instance by breathing enriched air nitrox (EANx) instead of air. This double blinded, randomized trial was designed to see if the use of EANx could effectively improve cognitive performance while diving. METHODS: Eight volunteers performed two no-decompression dry dives breathing air or EANx for 20 min at 0.4 MPa. Cognitive functions were assessed with a computerized test battery, including MathProc and Ptrail. Measurements were taken before the dive, upon arrival and after 15 min at depth, upon surfacing, and at 30 min postdive. After each dive subjects were asked to identify the gas they had just breathed.

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2018 Nis 3
Variability in circulating gas emboli after a same scuba diving exposure
Papadopoulou V., Germonpré P., Cosgrove D., Eckersley RJ., Dayton PA., Obeid G., Boutros A., Tang MX., Theunissen S., Balestra C.

PURPOSE: A reduction in ambient pressure or decompression from scuba diving can result in ultrasound-detectable venous gas emboli (VGE). These environmental exposures carry a risk of decompression sickness (DCS) which is mitigated by adherence to decompression schedules; however, bubbles are routinely observed for dives well within these limits and significant inter-personal variability in DCS risk exists. Here, we assess the variability and evolution of VGE for 2 h post-dive using echocardiography, following a standardized pool dive in calm warm conditions.

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2021 Oca 1
Increasing Oxygen Partial Pressures Induce a Distinct Transcriptional Response in Human PBMC: A Pilot Study on the “Normobaric Oxygen Paradox”
Fratantonio D, Virgili F, Zucchi A, Lambrechts K, Latronico T, Lafère P, Germonpré P, Balestra C.

The term “normobaric oxygen paradox” (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1α (HIF-1α) transcription factor activity. The molecular characteristics of this response have not been yet fully characterized. Herein, we report the activation time trend of oxygen-sensitive transcription factors in human peripheral blood mononuclear cells (PBMCs) obtained from healthy subjects after one hour of exposure to mild (MH), high (HH) and very high (VHH) hyperoxia, corresponding to 30%, 100%, 140% O2, respectively.

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2021 May 13
Impaired Attentional Processing During Parabolic Flight
Friedl-Werner A, Machado M-L, Balestra C, Liegard Y, Philoxene B, Brauns K, Stahn AC, Hitier M, Besnard S.

Previous studies suggest that altered gravity levels during parabolic flight maneuvers affect spatial updating. Little is known about the impact of the experimental setting and psychological stressors associated with parabolic flight experiments on attentional processes. To address this gap, we investigated the level of alertness, selective and sustained attention in 1 and 0 g using a Go/No-Go Continuous Performance Task. We also identified several parameters associated with the experimental set-up of a parabolic flight that could be expected to affect attentional processing.

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2021 Oca 1
Feasibility of Detecting Brain Areas Involved in Extreme Breath-Hold Diving
Jissendi-Tchofo P, Jdaoudi Y, Germonpré P, Brizzolari A, Musimu P, Balestra C.

We report Blood Oxygen Level Dependent (BOLD) signal changes recorded in the brain of an elite breath-hold diver during voluntary dry long breath-hold by means of fMRI. An independent component analysis (ICA) method was applied to extract brain areas that are putatively involved in the apnea process network. We discuss the hypothesis that these BOLD signal variations express the functional adaptive diving response under long apnea at rest. This is a preliminary report, which results are promising for large series investigations.

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