Tieteellisiä julkaisuja
Valikoituja tieteellisiä julkaisuja sukelluslääketieteestä ja -fysiologiasta.
2023 helmikuuta 7
Evaluation of the radical scavenging activity of some representative isoprenoid and aromatic cytokinin ribosides (N6-substituted adenosines) by in vitro chemical assays
Andrea Brizzolari, Mario C Foti, Luciano Saso, Pierangela Ciuffreda, Jelena Lazarević, Enzo Santaniello

Cytokinins are naturally occurring adenine derivatives whose physiological role is that of growth regulators in plants and that show also many other activities either in plants and in mammalian cells. In plants, they can be found mainly as free bases ((N6-substituted adenines, CKs), but also as the corresponding N9- ribosides (N6-substituted adenosines, CKRs). In mammalian cells, CKRs are, in general, more active than CKs. In order to evaluate the intrinsic in vitro antioxidant capacity of some significant CKRs, their scavenging activity against synthetic radicals that are at the basis of well-established antioxidant assays (ORAC, TEAC, DPPH) has been evaluated. The results of the in vitro scavenging activity of biologically relevant radicals such as hydroxyl (HO•), superoxide (O2.-) and lipid peroxides (R-OO.) are reported and discussed.

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2020 syyskuuta 28
Change in Oxidative Stress Biomarkers During 30 Days in Saturation Dive: A Pilot Study
Mrakic-Sposta S, Vezzoli A, D'Alessandro F, Paganini M, Dellanoce C, Cialoni D, Bosco G.

Saturation diving allows divers to reduce the risk of decompression sickness while working at depth for prolonged periods but may increase reactive oxygen species (ROS) production. Such modifications can affect endothelial function by exacerbating oxidative stress. This study investigated the effects of saturation diving on oxidative stress damage.

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2020 kesäkuuta 30
Experimental use of flow cytometry to detect bacteria viability after hyperbaric oxygen exposure: Work in progress report
Rozloznik M, Lochmanova A, Chmelar D, Hajek M, Korytkova K, Cisarikova M.

Introduction: Hyperbaric oxygen treatment (HBOT), based on inhaling pure oxygen under elevated ambient pressure, is used as adjuvant intervention to promote healing in infected wounds. Despite extensive clinical evidence of beneficial effects of HBOT in soft tissue infections the mechanism of action remains to be elucidated. The aim of this study was to evaluate the use of flow cytometry as a novel method to assess the viability of pathogenic bacteria after hyperbaric oxygen (HBO) exposure.

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2019 kesäkuuta 30
Early detection of diving-related cognitive impairment of different nitrogen-oxygen gas mixtures using critical flicker fusion frequency.
Lafère P, Hemelryck W, Germonpré P, Matity L, Guerrero F, Balestra C.

Introduction: Cognitive impairment related to inert gas narcosis (IGN) is a threat to diving safety and operations at depth that might be reduced by using enriched air nitrox (EANx) mixtures. Using critical flicker fusion frequency (CFFF), a possible early detection of cognitive abilities/cerebral arousal impairment when breathing different oxygen (O2) fractions was investigated.

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2020 tammikuuta 1
Hyperoxia and oxidative stress in anesthesia and critical care medicine
Ottolenghi S, Sabbatini G, Brizzolari A, Samaja M, Chiumello D.

Oxygen administration is particularly relevant in patients undergoing surgery under general anesthesia and in those who suffer from acute or critical illness. Nevertheless, excess O2, or hyperoxia, is also known to be harmful. Toxicity arises from the enhanced formation of reactive oxygen species (ROS) that, exceeding the antioxidant defense, may generate oxidative stress.

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