Bubbles can form in the body during or after decompression from pressure exposures such as those undergone by scuba divers, astronauts, caisson and tunnel workers. Bubble growth and detachment physics then becomes significant in predicting and controlling the probability of these bubbles causing mechanical problems by blocking vessels, displacing tissues, or inducing an inflammatory cascade if they persist for too long in the body before being dissolved...
Scopri di piùOBJECTIVES: Vasodilation of the peripheral arteries during reactive hyperaemia depends in part on release of nitric oxide from endothelial cells. Previous studies mainly employed a fingertip tonometric device to derive pulse wave amplitude (PWA) and PWA hyperaemic changes. An alternative approach is based on photoplethysmography (PPG). We sought to evaluate the correlates of digital PPG PWA hyperaemic responses as a measure of peripheral vascular function...
Scopri di piùINTRODUCTION: 'Decompression stress' is commonly evaluated by scoring circulating bubble numbers post dive using Doppler or cardiac echography. This information may be used to develop safer decompression algorithms, assuming that the lower the numbers of venous gas emboli (VGE) observed post dive, the lower the statistical risk of decompression sickness (DCS). Current echocardiographic evaluation of VGE, using the Eftedal and Brubakk method, has some disadvantages as it is less well suited for large-scale evaluation of recreational diving profiles. We propose and validate a new 'frame-based' VGE-counting method which offers a continuous scale of measurement...
Scopri di piùINTRODUCTION: Flying after diving may increase decompression sickness risk (DCS), but strong evidence indicating minimum preflight surface intervals (PFSI) is missing. METHODS: On return flights after a diving week on a live-aboard, 32 divers were examined by in-flight echocardiography with the following protocol: 1) outgoing flight, no previous dive; 2) during the diving week; 3) before the return flight after a 24-h PFSI; and 4) during the return flight. RESULTS: All divers completed similar multiple repetitive dives during the diving week. All dives were equivalent as to inert gas load and gradient factor upon surfacing. No bubbles in the right heart were found in any diver during the outgoing flight or at the preflight control after a 24-h PFSI following the diving week. A significant increase in the number and grade of bubbles was observed during the return flight. However, bubbles were only observed in 6 of the 32 divers. These six divers were the same ones who developed bubbles after every dive. CONCLUSIONS: Having observed a 24-h preflight interval, the majority of divers did not develop bubbles during altitude exposure; however, it is intriguing to note that the same subjects who developed significant amounts of bubbles after every dive showed equally significant bubble grades during in-flight echocardiography notwithstanding a correct PFSI. This indicates a possible higher susceptibility to bubble formation in certain individuals, who may need longer PFSI before altitude exposure after scuba diving.
Scopri di piùDecompression sickness (DCS) in rats is commonly modelled as a binary outcome. The present study aimed to develop a ternary model of predicting probability of DCS in rats, (as no-DCS, survivable-DCS or death), based upon the compression/decompression profile and physiological characteristics of each rat...
Scopri di più