Hyperbaric oxygen therapy (HBOT) is a therapeutical approach based on exposure to pure oxygen in an augmented atmospheric pressure. Although it has been used for years, the exact kinetics of the reactive oxygen species (ROS) between different pressures of hyperbaric oxygen exposure are still not clearly evidenced. In this study, the metabolic responses of hyperbaric hyperoxia exposures for 1 h at 1.4 and 2.5 ATA were investigated. Fourteen healthy non-smoking subjects (2 females and 12 males, age: 37.3 ± 12.7 years old (mean ± SD), height: 176.3 ± 9.9 cm, and weight: 75.8 ± 17.7 kg) volunteered for this study.
Lue lisääBackground: Transcutaneous neurostimulation (TNS) at extracephalic sites is a well known treatment of pain. Thanks to recent technical progress, the Cefaly® device now also allows supraorbital TNS. During observational clinical studies, several patients reported decreased vigilance or even sleepiness during a session of supraorbital TNS. We decided therefore to explore in more detail the potential sedative effect of supraorbital TNS, using standardized psychophysical tests in healthy volunteers.
Lue lisääCytokinins are naturally occurring adenine derivatives whose physiological role is that of growth regulators in plants and that show also many other activities either in plants and in mammalian cells. In plants, they can be found mainly as free bases ((N6-substituted adenines, CKs), but also as the corresponding N9- ribosides (N6-substituted adenosines, CKRs). In mammalian cells, CKRs are, in general, more active than CKs. In order to evaluate the intrinsic in vitro antioxidant capacity of some significant CKRs, their scavenging activity against synthetic radicals that are at the basis of well-established antioxidant assays (ORAC, TEAC, DPPH) has been evaluated. The results of the in vitro scavenging activity of biologically relevant radicals such as hydroxyl (HO•), superoxide (O2.-) and lipid peroxides (R-OO.) are reported and discussed.
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